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To report a case of atypical unilateral maculopathy associated with acute exudative polymorphous vitelliform maculopathy–like yellowish deposits.Observational case report of one patient.A 52-year-old man presented with reduced vision in the left eye. Findings resembling acute exudative polymorphous vitelliform maculopathy were noted with ophthalmoscopy, fluorescein angiography, and optical coherence tomography. Funduscopic examination revealed an exudative macular detachment with yellowish subretinal deposits inferior to the fovea. On fluorescein angiography, the perifoveal lesions were minimally hyperfluorescent, with no abnormal fluorescence in the central macula. The subretinal deposits were found to be hyperautofluorescent on fundus autofluorescence imaging. Optical coherence tomography confirmed a serous detachment of the retina with intraretinal cystic spaces. The right eye did not show any abnormalities except for an epiretinal membrane.We describe a case of atypical unilateral maculopathy associated with acute exudative polymorphous vitelliform maculopathy–like yellowish deposits.