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Ribosome Biogenesis is Necessary for Skeletal Muscle Hypertrophy

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Abstract

Muscle hypertrophy occurs when the rate of protein synthesis exceeds the rate of degradation. A main factor determining the rate of protein synthesis is ribosome abundance or translational capacity. The production of ribosomes is a primary determinant of translational capacity. Based on studies from our laboratory, we propose the novel hypothesis that ribosome biogenesis is necessary for skeletal muscle hypertrophy.

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