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After reading this article, the participant should be able to: 1. Understand the theory and principles behind successful avascular fat transfer; 2. Apply these principles into techniques that yield safe and successful fat grafting operations; 3. Identify the well-established indications and limitations of the various fat grafting operations as well as the indications that require additional clinical and translational research.In this article, the authors summarize the established principles and techniques of fat grafting, discuss debated topics, and present both the well-established and the novel clinical applications of fat grafting.