Etomidate: An Ultrashort-Acting Nonbarbiturate Agent for Anesthesia Induction


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Abstract

Clinical evaluation of etomidate, an ultrashort-acting nonbarbiturate hypnotic agent, shows it to be useful for anesthetic induction in adults. It produces sleep in 1 arm-brain circulation time, metabolites apparently peaking at 7 minutes post injection. Cardioyascular and respiratory systems appear minimally affected and there is no indication of organ toxicity or other biochemical or hematologic drug-induced disturbances. Moderate pain on injection at some sites and transient myoclonia were the principal disadrantages observed.

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