Health-related quality of life and utilities in primary-care patients with generalized anxiety disorder

    loading  Checking for direct PDF access through Ovid

Abstract

Background

Generalized anxiety disorder (GAD) is prevalent and significantly impacts patient health-related quality of life (HRQL) and disability.

Purpose

This study evaluated the effect of GAD and anxiety symptom severity on the HRQL of primary-care patients with GAD.

Methods

Patients 18 years or older with GAD were recruited from an integrated health care delivery system. Clinical assessments included the Hamilton Anxiety Rating Scale (HAM-A), GAD Questionnaire-IV (GAD-Q-IV), and the Patient Health Questionnaire depression module (PHQ). HRQL was assessed by the Quality of Life Enjoyment and Satisfaction Questionnaire—Short Form (Q-LES-Q-SF), Sheehan Disability Scale (SDS), SF-12 Health Survey (SF-6D), and the Health Utilities Index (HUI2, HUI3).

Results

The sample included 297 patients, 72% women with mean ± standard deviation (SD) age of 47.6 ± 13.7 years. At baseline, the mean HAM-A score was 16.8 ± 7.6 (suggesting the presence of moderate anxiety symptoms). Anxiety and depression symptoms were significantly correlated with mental component summary (MCS), Q-LES-Q-SF, SDS, SF-6D, HUI2, and HUI3 scores (all P < 0.001). The mean HRQL and all of the preference-based measures varied significantly by anxiety severity groups (all P < 0.001). Anxiety and depression symptoms significantly predicted HRQL and preference-based scores (R2 values ranged from 0.22 to 0.57).

Conclusions

Anxiety symptoms reported by GAD patients resulted in significant impairment to HRQL and functional outcomes.

Related Topics

    loading  Loading Related Articles