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A rare case of isolated liver metastases in a patient with recurrent glioblastoma multiforme (GBM) treated with surgery, chemotherapy, external beam irradiation, and salvage stereotactic radiosurgery is described. Our review of literature has revealed only 8 other cases of isolated liver metastases in patients with GBM in the last three decades. Recent data suggest that stereotactic radiosurgery may alter the prognosis of specific subsets of patients with GBM. The potential for combined modality therapy, including radiosurgery to impact on the survival of GBM patients, and, hence, the natural history of this disease, is discussed.