The purpose of this study was to evaluate the effects of the gantry angulation on dose profiles along the z-axis, the CTDIW value and the CTDIW efficiency in the head examinations. A Monte Carlo simulation model of a GE LightSpeed 16-slice CT scanner was developed by a GATE toolkit. The CTDI100 in air at the isocenter and in a head dosimetry phantom were measured using a pencil ion chamber. Dose profiles were studied in the central and peripheral holes of the head phantom using thermoluminescence LiF disc dosemeters for gantry angulations of 0°, 10° and 20°. Results show a small shift for only the peripheral dose profiles with increasing the gantry angulation (maximum shift of 24 mm at 20°). The peak amplitude of the dose profiles was reduced for both of the central and peripheral holes by ˜5%, while the CTDIW values and the CTDIW efficiencies did not change significantly.