HYDROGENATION OFMETHYL 3α-ACETOXY-23-OXO-5β-CHOLAN-24-OATECATALYZED BY CINCHONA ALKALOID-MODIFIED PT-ALUMINA CATALYST


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Abstract

Methyl-3α-acetoxy-23-oxo-5β-cholan-24-oate is hydrogenated with 78% enantioselection at C23 atom over Pt-alumina catalyst modified with cinchona alkaloids, in liquid phase under mild experimental conditions (293-297 K, hydrogen pressure: 1 bar, concentration of modifiers: 0.1 mmol/L, solvent: THF).

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