β-agonists found to increase mortality in early ARDS
SNRIs increase risk of falls in elderly
Lamotrigine may increase risk of death in females
Drospirenone ups risk of VTE, PE, but not TIA, stroke
No increased risk of death with long-term antiretrovirals
Thyroid dysfunction common with novel antineoplastics
ADHD drugs not linked with serious CV events in adults
UK MHRA reminds consumers to use registered herbal products
Opioid-related AEs extract large cost burden in the US
QT-interval prolongation associated with citalopram and escitalopram is dose-dependent,
Reports of severe ocular disorders linked to bevacizumab
The US FDA is to review postmarketing reports of serious bleeding associated with dabigatran etexilate
Safety info for dronedarone updated in Canada
EMA takes further action at Ben Venue
The US FDA has updated the REMS* for both romiplostim [Nplate] and eltrombopag [Promacta].
Acenocoumarol : Intramural gastric haematoma: case report
Acenocoumarol/fluindione/warfarin : Necrotic leg ulcers in elderly patients: 5 case reports
Acetylcysteine overdose : Haemolysis and haemolytic uraemic syndrome after a dosing error: case report
Adalimumab : Palmoplantar pustulosis: case report
Amlodipine overdose : Pulmonary oedema: case report
Amikacin/ethambutol : Blindness and deafness: case report
Alemtuzumab : Toxoplasmosis: case report
Adalimumab/infliximab : Cutaneous infection with Mycobacterium marinum: 2 case reports
Antineoplastics/mesna : Acute respiratory distress and renal failure: case report
Antineoplastics : Tracheal necrosis following inadvertent mediastinal administration: case report
Antineoplastics : Fatigue, dry skin and peripheral neuropathy: case report
Aripiprazole : Various toxicities: 5 case reports
Arsenic trioxide/fluconazole/fluvoxamine interaction : QT interval prolongation, and SSRI discontinuation syndrome following fluvoxamine withdrawal: case report
Atazanavir/ritonavir/tacrolimus interaction : Renal failure and drowsiness: case report
Aspirin/clopidogrel : Spontaneous spinal epidural haematoma: case report
Betamethasone/haloperidol : Hyperammonaemic coma in an ornithine transcarbamylase mutation carrier: case report
Azathioprine/rituximab : Various toxicities: 5 case reports
Azathioprine/infliximab : Actinomyces osteomyelitis in an elderly patient: case report
Basiliximab/ciclosporin interaction : Renal cortical necrosis: case report
Bevacizumab : Hypertension and atrial fibrillation: case report
Bevacizumab : Osteonecrosis of the jaw: case report
Bisphosphonates/glucocorticoids : Metatarsal stress fractures: 6 case reports
Buprenorphine : Various toxicities after transdermal administration in children: case report
Bupropion : Ataxia, tremor and mental status changes in an elderly patient: case report
Bleomycin : Pneumonitis: case report
Bupropion : Hypotension and seizures treated with soya oil emulsion: case report
Capecitabine/oxaliplatin : Portal pneumatosis and rectal mucositis in an elderly patient: case report
Carboplatin/gemcitabine : Leucopenia and progressive multifocal leukoencephalopathy in an elderly patient: case report
Cabergoline : Brain and optic chiasmal herniation into pituitary sella: case report
Ceftriaxone : DRESS syndrome, and CMV oesophagitis and duodenitis: case report
Carvedilol withdrawal : Exacerbation of benign prostatic hyperplasia, manifesting as urinary retention in an elderly patient: case report
Cefepime : Neurotoxicity in patients receiving maintenance haemodialysis: 2 case reports
Cetuximab : Pustular folliculitis: case report
Ciclosporin : Nephrotoxicity in children: 2 case reports
Ciprofloxacin/warfarin interaction : Gastrointestinal bleeding in an elderly patient: case report
Cetuximab : Desquamation, cheilitis and stomatitis in an elderly patient following radiotherapy: case report
Chlorpromazine : Photoallergic contact dermatitis: 3 case reports
Colchicine : Poisoning, leading to various toxicities in paediatric patients: 23 case reports
Cisplatin/etoposide/ifosfamide : Hearing disturbances and myelosuppression: 14 case reports
Citric acid/gluconolactone/magnesium carbonate : Respiratory insufficiency: case report
Contrast media : Immediate hypersensitivity: 30 case reports
Dabigatran etexilate : Exanthema: case report
Dapsone/ferrous oxalate : Haemolysis: case report
Cyclobenzaprine : Neuroleptic malignant syndrome: case report
Corticosteroids/methoxsalen/prednisone : Various toxicities: case report
Daptomycin : Acute eosinophilic pneumonia: case report
Dexamethasone : Legionella pneumophila infection leading to lung abscess: case report
Diazepam/levomepromazine overdose : Unconsciousness, followed by deep vein thrombosis and compartment syndrome: case report
Digoxin overdose : Bradycardia following a medication error in a neonate: case report
Edrophonium/pyridostigmine : Hypersalivation and muscle fasciculations: case report
Erlotinib : Skin toxicity: 2 case reports
Ethylene oxide : Anaphylaxis: case report
Enoxaparin sodium : Hypersensitivity in an elderly patient: case report
Epinephrine : Ischaemia following accidental autoinjection treated with papaverine: case report
Fenofibrate : Rhabdomyolysis and renal failure: case report
Flecainide : Brugada pattern ECG: case report
Everolimus/ridaforolimus : Stomatitis: 17 case reports
Etodolac : Collagenous colitis: case report
Ghrelin : Hypothermia (first report) in an elderly patient: case report
Gadolinium-containing contrast agents : Hypersensitivity: 11 case reports
Fluorescein : Anaphylaxis: case report
Ginkgo biloba : First report of paroxysmal atrial fibrillation: case report
Herbal medicines : Skin necrosis: case report
Haloperidol/moxifloxacin/sotalol : Macrovolt T-wave alternans leading to ventricular tachycardia in an elderly patient: case report
Ifosfamide/methotrexate : Neurological disorders in an infant: case report
Hydrocortisone : Hallucinatory psychosis: case report
Hydroxychloroquine : Restrictive cardiomyopathy: case report
Immune globulin : Membranous glomerulopathy: case report
Infliximab : Systemic lupus erythematosus: case report
Influenza virus vaccine/influenza A virus vaccine-H1N1 : Miller Fisher syndrome in an elderly patient: case report
Infliximab : Agranulocytosis: case report
Infliximab : Autoimmune hepatitis: case report
Infliximab : Drug-induced lupus erythematosus: case report
Lenalidomide : Diffuse alveolar haemorrhage in an elderly patient: case report
Levamisole : Necrosis of the ears in a cocaine user: case report
Levothyroxine sodium withdrawal : Hyponatraemia in an elderly patient: case report
Insulin aspart : Lipoatrophy: case report
Metandienone/nandrolone : Myocardial toxicity: case report
Lopinavir/ritonavir/tenofovir : Renal impairment: 2 case reports
Lithium/risperidone : Exacerbation of stuttering in a child: case report
Mirtazapine : Manic switch: case report
Nitrofurantoin : Autoimmune hepatitis in an elderly patient: case report
Methotrexate : Intestinal perforation: case report
Methotrexate : Medial tibial stress syndrome: case report
Omeprazole : Emphysematous gastritis: case report
Nitroglycerin : Tachycardia and chest pain?: case report
Paracetamol overdose : Liver failure in a pregnant woman: case report
Pegvisomant : Liver injury: case report
Paracetamol overdose : Acute liver failure and encephalopathy: case report
Quetiapine abuse : Dependence and withdrawal symptoms: case report
Pyrimethamine overdose : Various toxicities in a neonate: case report
Progesterone : Eosinophilic pneumonia associated with sesame oil excipient following IM administration: case report
Pramipexole : Gambling, hypersexuality and impotence in an elderly patient: case report
Ritodrine : Pustular eruption: case report
Rituximab : Fibrosing cholestatic hepatitis: 4 case reports
Roxatidine : Psoriasiform eruption: case report
Sorafenib : Erythrodysaesthesia: case report
Sirolimus : Pulmonary alveolar proteinosis: case report
Sorafenib : Desquamative interstitial pneumonia: case report
Salbutamol : Lactic acidosis: case report
Sulfasalazine : Systemic lupus erythematosus: case report
Sunitinib : Pneumatosis cystoides intestinalis in an elderly patient: case report
Sorafenib/sunitinib : Thrombocytopenia, vomiting, hypertension and erythrodysaesthesia: case report
Sunitinib : Aneurysm rupture in an elderly patient: case report
Tigecycline : Development of tigecycline-resistant Escherichia coli, treated with colistin: case report
Tocilizumab : Organising pneumonia: case report
Trastuzumab : First report of sarcoidosis: case report
Tretinoin : Genital ulceration progressing to Fournier gangrene: case report
Vancomycin : Linear IgA bullous dermatosis in an elderly patient: case report
Verapamil : Increased frequency of torsades de pointes in an infant: case report
Valproate semisodium overdose : Various toxicities, treated with levocarnitine and haemofiltration: case report
Verapamil overdose : AV block, hypotension and other toxicities, treated with soya oil emulsion: case report
Warfarin : Rectus sheath haematoma: case report
Warfarin : Gastrointestinal haemorrhage in an elderly patient: case report