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This study investigated various aspects of stress experienced by primary caretakers of chronic physically disabled children and adults. Overall stress and the levels of stress experienced in different areas were compared for the two groups. There was a trend for overall stress to be greater for caretakers of adults, and significant differences were found in specific areas of stress. Caretakers of children experienced higher stress related to cognitive impairment and life span care, while caretakers of adults reported greater stress related to lack of personal reward, terminal illness stress, physical limitations, and preference for institutional care. Income level was inversely related to overall stress for caretakers of children, but not for caretakers of adults.