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Computer and information technologies have the potential both to enhance the lives of people with disabilities as well as to deny them equality of access to education, jobs, and community life. In particular, these new technologies have the potential to enable or to create difficulties for people with disabilities in the new knowledge-based economy. Concerns about these technologies and their accessibility are evolving issues for the next decade. The authors summarize the findings of a 5-year research program that involved over 1,000 participants from postsecondary educational institutions across Canada. They then highlight emerging issues. Finally, they make broad-based recommendations to rehabilitation psychologists.