Stewart-Treves Syndrome in a Patient Following Mastectomy: A Case Report

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Stewart-Treves syndrome (STS) is a rare and deadly entity, involving the development of lymphangiosarcoma in chronically lymphedematous upper extremities following mastectomy.

Case Description:

A 57-year-old woman presented with a 3-month history of rapidly growing, painful skin lesions on her left distal forearm. Fourteen years previously, she had undergone a radical mastectomy with axillary lymph node dissection, adjuvant chemotherapy, and radiation therapy due to invasive left breast cancer. A surgical biopsy specimen obtained from the lesion revealed a high-grade angiosarcoma, indicative of STS. Magnetic resonance imaging and whole-body positron emission tomography revealed that the left distal forearm lesion extended to the condyle of the left humerus. The patient underwent a transhumeral amputation of the left upper limb, and an 8-month combination chemotherapy regimen was scheduled. She is still alive 22 months after the diagnosis of STS.


This study may increase the clinician's awareness regarding the occurrence of STS in patients with chronic lymphedema, especially after mastectomy.

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