Survival of mouse ovarian tissue transplanted into the uterine horn of postpartum rats nursing pups of various numbers and sizes


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Abstract

Aim and background:To investigate the effect of the number of pups being nursed on the survival of mouse ovarian tissue transplanted into the post-partum rat uterus.Methods:Mouse ovarian tissue was transplanted into the uterine horn of post-partum rats. The number of pups nursed by each recipient rat was adjusted in a manner predetermined. Examinations were undertaken at 1–11 weeks after transplantation. Ovarian tissue containing healthy follicles was considered to have taken successfully.Results:In rats with 12 pups, ovarian tissue remained viable at 11 weeks post-transplantation. No viable ovarian tissue remained when there were one or two pups. Viability improved as the number of pups increased.Conclusion:When mouse ovarian tissue is transplanted into post-partum lactating rats, viability improves as the number of pups increases. We concluded that these findings may be explained in terms of progesterone levels in the recipient rats.

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