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There have been controversial reports regarding the relationship between exercise tolerance and resting pulmonary function in patients with COPD. The aim of this study was to examine the relationship between resting pulmonary function tests (rPFT) and cardiopulmonary exercise testing parameters (CETP) and their value in estimating exercise tolerance of patients.In total, 45 patients with COPD (nine females, 36 males; mean age 61.2 ± 11.2) and 21 healthy subjects (four females, 17 males; mean age 60.3 ± 9.7) as a control group were studied. COPD patients (group I) were divided into three subgroups according to their FEV1 (mild/group II: FEV1 60–79% of predicted; moderate/group III: FEV1 40–59%; severe/group IV: FEV1 < 40%). In controls FEV1 was ≥ 80%.There were significant correlations between FEV1 and CETP in group III (maximal O2 consumption (mVO2), r= 0.35, P < 0.005; total treadmill time (TTT), r= 0.31, P < 0.01; total metabolic equivalent values (TMET), r= 0.29, P < 0.01)) and in group IV (mVO2, r= 0.49, P < 0.001; TTT, r= 0.45, P < 0.005; TMET, r= 0.31, P < 0.01; peak heart rate (pHR), r= 0.29, P < 0.02; frequency of ventricular extrasystole (fVES), r=−0.27, P < 0.05). Additionally, in group IV there were significant correlations between PaO2 and CETP (mVO2, r= 0.41, P < 0.02; TTT, r= 0.38, P < 0.03; TMET, r= 0.31, P < 0.05; pHR, r= 0.29, P < 0.05; fVES, r=−0.28, P < 0.05).There are significant correlations of resting FEV1% predicted and PaO2 values with CETP in patients with moderate and severe COPD and these parameters may also have a role as indicators of exercise tolerance in these COPD patients.