Elevated circulating cytotoxic T lymphocyte-associated antigen-4 levels are related to lung function and inflammation in chronic obstructive pulmonary disease

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Abstract

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is involved in immune and inflammation regulation. The present study aimed to investigate the association between CTLA-4 and COPD. Data revealed that serum levels of CTLA-4 were elevated in COPD patients, inversely correlated with lung function and positively correlated with serum C-reactive protein levels in the COPD group. These findings suggest that CTLA-4 may play a role in COPD.

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