AbstractBackground and objective:
Nontuberculous mycobacterial (NTM) lung disease secondary to cystic fibrosis (CF) has been reported, but there is limited data about NTM prevalence in non-CF bronchiectasis. We retrospectively investigated the prevalence of NTM associated with diffuse panbronchiolitis (DPB), a disorder also characterized by reduced mucociliary clearance with bronchiectasis.Methods:
We reviewed mycobacterial cultures, patient characteristics and computed tomography findings of 33 patients with DPB between January 2000 and December 2012. Prevalence was based on at least one positive NTM culture.Results:
Mean patient age was 51.5 years. During a mean 162.8-month follow-up, the prevalence of NTM in sputum was 21.2% (seven patients). Of the seven positive patients, six hadMycobacterium aviumcomplex, one hadM. kansasiiandM. chelonaeco-cultured withM. aviumcomplex. Three patients were positive twice, and two had positive smears. The mean time from DPB diagnosis to the first positive result was 194.6 months. NTM-positive patients tended to have lower forced expiratory volume in 1 s (% predicted) than NTM-negative patients (50.0% vs 77.3%,P= 0.03), but there were no radiological or clinical differences between the two groups.Conclusions:
Our observations suggest that NTM is found more often in DPB. Defects of mucociliary clearance may predispose individuals to NTM infection.SUMMARY AT A GLANCE
Defects in the mucociliary transport system are assumed to be a predisposing factor to nontuberculous mycobacterial (NTM) infection. We retrospectively investigated the prevalence of NTM associated with diffuse panbronchiolitis (DPB), which is characterized by mucociliary dysfunction. We detected a high prevalence comparable to rates in cystic fibrosis.