INTRAVITREAL TRIFLUOROTHYMIDINE AND RETINAL TOXICITY


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Abstract

Intraocular trifluorothymidine was administered to one group of albino rabbits as an intravitreal injection, and to a second group of albino rabbits in the infusion solution during pars plana vitrectomy. The eyes of both populations were evaluated with preoperative and postoperative indirect ophthalmoscopy, electroretinography, and histologic examination. From these data, it was determined that an intravitreal injection of 200 μg/0.1 ml and a vitrectomy solution containing a concentration of 60 μg/ml triflucrothymidine were nontoxic to the rabbit eye.

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