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Leptospirosis is generally significant zoonotic disease and an important public health problem in developing countries. Because of primary antibiotic treatment importance in this disease, early diagnosis is essential for appropriate managing. Laboratory tests for the early diagnosis of disease are necessary. PCR is not sole useful for diagnosis, as it is unavailable in most developing countries. Microscopic agglutination test and the ELISA are not suitable leptospirosis tests for early diagnosis, but they can be taken as gold standard methods for leptospirosis diagnosis, especially as complementary tests in a corelation with molecular methods. Leptospirosis detection rate is increased by combining antibody and DNA detection, providing a new tool for timely diagnosis and confirmation of infection.