Is a History of Gestational Diabetes Related to Risk Factors for Coronary Heart Disease?

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Coronary heart disease (CHD) risk in 20 non-diabetic women with and 20 without a distant history of gestational diabetes (hGDM), matched on age, body mass index, and time since GDM-affected pregnancy, was compared in a case control study. Women with an hGDM had lower high-density lipoprotein cholesterol (HDL-c), p=.02, and higher triglycerides, p≤.001, versus controls. The combination of high triglycerides and low HDL-c occurred in 25% of hGDM cases versus 0% of controls, p≤.01. Two-hour post-load glucose indicated that 45% of hGDM cases were pre-diabetic versus 20% of controls, p≤.05. Non-diabetic women with a distant hGDM are at increased risk for DM and may be at increased risk for CHD.

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