This article tests the hypothesis that “if redundancy-oriented management has negative aspects, then it could be facilitated by gene-therapy-oriented management.” Negative aspects include disadvantages, misjudgments, or miscalculations. The article provides a newly revised principle of disaster management by studying gene-therapy-oriented management. Based on qualitative analysis, redundancy-oriented and gene-therapy-oriented management are analyzed via five variables: governments, business, volunteers, households, and the international community. The article is valuable because an analytical frame on gene-therapy-oriented management is systematically reconceptualized for the field of disaster management via three elements: unhealthy proteins (problems or failed measures), a vector (new or modified solutions), and target cells (positive outcomes). In accepting the hypothesis, the key tenet is that stakeholders have to assist the progress of redundancy-oriented management with gene-therapy-oriented management by paying attention to the genes of each disaster.