Methicillin resistance has been recognized in Staphylococcus aureus since the 1960s and is now endemic worldwide. Resistance to this antibiotic and several others have made methicillin-resistant Staphylococcus aureus (MRSA) a major cause of infection. It is now a significant cause of infection in the community as happened some 30 years ago with penicillin resistance in the same bacterial pathogen. Considerable effort is now being devoted to the development of better ways of controlling infection. These include changes in hospital management, prudent appropriate use of antibiotics and development of new modalities for treatment of infection. This review will attempt to forecast the future picture of MRSA infection and its control over the next 10–15 years. The value and possible impact of new antibiotics with novel modes of action, vaccines and antibodies will be discussed.