AIDS is a disease, caused by the HIV belonging to the retroviral family, transmitted through blood, body fluids and unprotected sexual contact that may involve a number of complications of immune, cardiovascular and pulmonary systems. Antiretroviral drugs are usually used in treatment. Mild bone loss occurs with the start of antiretroviral treatment. Bone mass seems to be constant and improved in prolonged use of antiretrovirals. Oral and parenteral bisphosphonates are useful in patients, and they are referred to first-line treatment to prevent frailty and bone rupture.