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The genetically modified (GM) soybean FG72 contains two exogenous genes: p-hydroxyphenylpyruvate dioxygenase (hppd) and double mutant 5-enol pyruvylshikimate-3-phosphate synthase (2mepsps), endowing the FG72 with the glyphosate and isoxaflutole herbicides resistant abilities for presence of the 2mEPSPS and HPPD W336 proteins. A food safety assessment of GM soybean FG72 was evaluated by a 90-days feeding study using three different dietary concentrations (7.5%, 15%, or 30% w/w) of the GM soybean or its corresponding non-GM cultivar Jack fed to Sprague-Dawley rats. In our study, no biologically significant differences on animal daily clinical signs, body weights, clinical observations, hematology, clinical chemistry, histopathology on selected organs were observed within the GM soybean groups and among the GM soybean groups, the non-GM soybean groups and the control group. The results of the 90-days subchronic feeding study demonstrated that the GM soybean FG72 is as safe as the conventional non-GM soybean Jack.A 90-days subchronic feeding study of multiple herbicide-resistance soybean was carried out.No observed toxicological effects were found in rats with up to 30% inclusion diets.The soybean FG72 was as safe as the non-genetically modified soybean Jack in this study.