Chemical and Chemoenzymatic Synthesis of Nucleoside 5′-α-Thiotriphosphates

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New methods of chemical and chemoenzymatic synthesis of nucleoside 5′-thiophosphates and 5′-α-thiotriphosphates are developed. The 5′-α-thiotriphosphates are used as substrates both in template-dependent enzymatic PCR synthesis and in a T7–RNA transcription polymerase system.

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