Some Derivatives of 5α-Ketosteroid Hydrazones: Synthesis from Tigogenin and Antituberculosis Activity


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Abstract

Isonicotinoylhydrazones and thiosemicarbazones of some 5α-ketosteroids were synthesized from tigogenin, and their structures were confirmed by NMR and IR spectroscopy and mass spectrometry. Their antimycobacterial activities were studied and it was shown that some of the synthesized isonicotinoylhydrazones exhibit a high antituberculosis activity.

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