Synthesis of Cationic Amphiphiles on the Basis of Deoxycholic Acid


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Abstract

Cationic derivatives of deoxycholic acid with N,N-dimethylenediamine, ε-aminocaproic acid, and pyridine as polar heads were synthesized. The cationic groups were linked to 3α- and 12α-hydroxy groups of the steroid moiety through ester or urethane bonds. Liposomal formulations of the compounds synthesized may be used for gene delivery in cells.

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