Synthesis of thio-and selenophospholipids from 2,2,5,5-Tetra(hydroxymethyl)cyclopentanone


    loading  Checking for direct PDF access through Ovid

Abstract

New phospholipids, thio-and selenoanalogues of phosphatidic acids, were synthesized on the basis of 2,2,5,5-tetra(hydroxymethyl)cyclopentanone. The starting tetraol monoketal was phosphorylated with amidophosphorous acid chlorides to protected polyol amidophosphites, which were further sulfurized or selenized to phosphoacetals. These were directly acylated with fatty acid chlorides to thio-and selenoanalogues of phospholipids.

    loading  Loading Related Articles