Synthesis of thio-and selenophospholipids from 2,2,5,5-Tetra(hydroxymethyl)cyclopentanone

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New phospholipids, thio-and selenoanalogues of phosphatidic acids, were synthesized on the basis of 2,2,5,5-tetra(hydroxymethyl)cyclopentanone. The starting tetraol monoketal was phosphorylated with amidophosphorous acid chlorides to protected polyol amidophosphites, which were further sulfurized or selenized to phosphoacetals. These were directly acylated with fatty acid chlorides to thio-and selenoanalogues of phospholipids.

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