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An in vitro treatment of solanaceous plants, viz. potato (Solanum tuberosum L.) and tobacco (Nicotiana tabacum L.), with lysophosphatidylcholine promoted their resistance to phytopathogens, such as Phytophthora infestans (Mont.) de Bary and potato virus Y. The systemic and long-term lysophospholipid-induced response was independent of the phytopathogen type. It was concluded that lysophosphatidylcholine, a product of phosphatidylcholine hydrolysis with phospholipase A2, plays an important role in the regulation of plant immune system.