Methylene Blue: Magic Bullet for Vasoplegia?

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(Abstracted from Anesth Analg, 122:194–201, 2016)

The perioperative and critical care literature recently has devoted considerable attention to methylene blue (MB) because it has the ability to antagonize the profound vasodilation encountered in distributive (also known as vasodilatory or vasoplegic) shock states. This comprehensive review article discusses the pharmacologic characteristics of MB and reviews the critical care, liver transplantation, and cardiac anesthesia literature featuring the efficacy and safety of MB for the treatment of shock.

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