Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism

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(Abstracted from Anesthesiology, 123:1142–1153, 2015)

Methadone is a long-duration opioid used for pain treatment and is a cornerstone therapy for opioid addiction and public health strategy for human immunodeficiency virus/acquired immunodeficiency syndrome and hepatitis C reduction. It is typically a racemic mixture.

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