Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery

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(Abstracted from Anesth Analg, 121:861–867, 2015)

Postoperative atrial fibrillation (POAF), defined in this study as supraventricular tachycardia with absence of distinct p-waves and irregular R-R intervals, has a peak incidence on postoperative day 2 and is associated with increased cardiovascular, renal, and cerebral morbidity and mortality. It is thought magnesium (Mg) may have beneficial effects on preventing POAF because hypomagnesemia may promote atrial fibrillation (AF) through prolongation of the atrial effective refractory period, reduction of myocardial excitability, and decreased rates of diastolic depolarization of sinoatrial pacemaker cells.

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