Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients

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(Abstracted from Anesthesiology, 122:1112–1122, 2015)

There is a high prevalence of acute postoperative pain in cardiac surgical patients, especially during the first 2 days after surgery. Indeed, most patients have reported moderate to severe pain during intensive care unit (ICU) admission, even with treatment with potent opioids.

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