Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction

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(Abstracted from Anesthesiology, 124:352–361, 2016)

Approximately 16% to 21% of elderly patients are afflicted with postoperative cognitive dysfunction (POCD) 3 months after anesthesia and surgery, and this complication is associated with adverse outcomes. Although the precise cause of POCD remains undetermined, the authors hypothesized that geriatric persons with Alzheimer disease (AD) neuropathology, detected by cerebrospinal fluid (CSF) analysis, would have an increased risk for POCD.

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