The Effect of Dexmedetomidine on Outcomes of Cardiac Surgery in Elderly Patients

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(Abstracted from J Cardiothorac Vasc Anesth, 30(6):1502–1508, 2016)

The purpose of this retrospective investigation was to study the effects of the perioperative use of dexmedetomidine (Dex) on outcomes in elderly patients undergoing cardiac surgery. Dexmedetomidine, a highly selective α2-adrenergic agonist, controls the activity of the sympathetic nervous system by binding to the α2-receptors present in both the central and peripheral nervous systems and inhibiting the release of norepinephrine, thus modulating sympathetic activity.

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