Disconnecting Consciousness: Is There a Common Anesthetic End Point?

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(Abstracted from Anesth Analg, 123(5):1228–1240, 2016)

The purpose of this review on the “Common Anesthetic End Point” was to comprehensively review the neuroscientific basis for anesthetic-induced loss and return of consciousness. Topics covered included a review of the importance of information integration in consciousness; early studies of network breakdown during anesthesia; preclinical, translational, and clinical research demonstrating disrupted frontal-to-parietal connectivity during anesthesia; and an update on the potential mechanisms of this functional disruption.

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