Effect of Propofol, Sevoflurane, and Isoflurane on Postoperative Cognitive Dysfunction Following Laparoscopic Cholecystectomy in Elderly Patients: A Randomized Controlled Trial

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Abstract

(Abstracted from J Clin Anesth, 38:165–171, 2017)

Postoperative cognitive dysfunction (POCD) caused by surgical trauma and general anesthetics results in mortality and morbidity in surgical patients, especially the elderly (severe in aged >60 years). This randomized, double-blind clinical trial aimed to compare the incidence of POCD in elderly surgical patients receiving different anesthetics (propofol, sevoflurane, or isoflurane) and to identify potential biomarkers of POCD in elderly patients.

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