Implementing a Statistical Model for Protamine Titration: Effects on Coagulation in Cardiac Surgical Patients

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(Abstracted from J Cardiothorac Vasc Anesth, 31:516–21, 2017)Using a fixed protamine-heparin dose (1:1) is the most commonly used method of protamine dosing in cardiopulmonary bypass patients to reverse the effects of heparin. The hemostasis management system (HMS Plus; Medtronic, Minneapolis, Minn) is an accepted alternate point-of-care device to calculate protamine dosing.

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