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We describe an immunocompromised patient, aged 78 y, with urinary tract infection caused by Kluyvera ascorbata. Complete recovery was achieved on antibiotic therapy with ceftriaxone. Review of the literature clearly indicates that K. ascorbata is a potentially dangerous pathogen either in the immunocompetent or in the immunocompromised host. K. ascorbata, and in general Kluyvera species, deserve prompt identification in order to determine antimicrobial susceptibility pattern and a correct and aggressive antibiotic treatment.