Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

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Abstract

The E2F family of transcription factors functions in the control of the mammalian cell cycle.Here it is shown that two family members, E2F-1 and DP-1, form specific heterodimers in vivo, a process that enhances DNA binding, transactivation, and the binding of the retinoblastoma gene product. These results suggest that heterodimerization regulates E2F function and contributes to cell cycle control.

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