Interleukin-2 Receptor ``gamma'' Chain: A Functional Component of the Interleukin-4 Receptor

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The interleukin-2 (IL-2) receptor ``gamma'' chain (IL-2R``gamma'') is an essential component of high- and intermediate-affinity IL-2 receptors. IL-2R``gamma'' was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL-2R``gamma'' to augment IL-4 binding affinity, and the requirement for IL-2R``gamma'' in IL-4-mediated phosphorylation of insulin receptor substrate-1. The observation that IL-2R``gamma'' is a functional component of the IL-4 receptor, together with the finding that IL-2R``gamma'' associates with the IL-7 receptor, begins to elucidate why deficiency of this common ``gamma'' chain (``gamma'' sub c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

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