Attachment of Helicobacter pylori to Human Gastric Epithelium Mediated by Blood Group Antigens

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Abstract

Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans.The Lewis sup b (Leb) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Le sup b antigen or antibodies to the Leb antigen inhibited bacterial binding. Gastric tissue lacking Leb expression did not bind H. pylori. Bacteria did not bind to Leb antigen substituted with a terminal GalNAc``alpha''1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.

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