Magnetic Field Effects on B: Evidence for a Radical Mechanism12: Evidence for a Radical Mechanism Ethanolamine Ammonia Lyase: Evidence for a Radical Mechanism

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Abstract

A change in radical pair recombination rates is one of the few mechanisms by which a magnetic field can interact with a biological system.The kinetic parameter Vmax/Km (where K (m) is the Michaelis constant) for the coenzyme B12-dependent enzyme ethanolamine ammonia lyase was decreased 25 percent by a static magnetic field near 0.1 tesla (1000 gauss) with unlabeled ethanolamine and decreased 60 percent near 0.15 tesla with perdeuterated ethanolamine. This effect is likely caused by a magnetic field-induced change in intersystem crossing rates between the singlet and triplet spin states in the {cob(II)alamin:5 prime-deoxyadenosyl radical}spin-correlated radical pair.

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