After 14 years in pharmaceutical discovery research, the first day of my new career in project management was disorienting. I was still at the company where I had been working as a researcher, but now my office was on the opposite side of the building. It had taken me a long time, and a lot of fits and starts, to get here. Between graduate school and two postdocs, I had spent nearly 12 years preparing for a career in pharmaceutical research, and I was reluctant to leave it. But after giving research three chances, I decided that it was time to explore a different path. Now, two-and-a-half years later, I don't regret my decision to leave the lab, and I am enjoying this second act of my career.