Inactivation of the Type II TGF-beta Receptor in Colon Cancer Cells with Microsatellite Instability

Sanford Markowitz;Jing Wang;Loi Myeroff;Ramon Parsons;LuZhe Sun;James Lutterbaugh;Robert S. Fan;Elizabeth Zborowska;Kenneth W. Kinzler;Bert Vogelstein;Michael Brattain;James K. V. Willson;

Science. 268(5215):1336-1338, JUNE 2, 1995

Issn Print: 0036-8075

Publication Date: June 2, 1995

Sanford Markowitz;Jing Wang;Loi Myeroff;Ramon Parsons;LuZhe Sun;James Lutterbaugh;Robert S. Fan;Elizabeth Zborowska;Kenneth W. Kinzler;Bert Vogelstein;Michael Brattain;James K. V. Willson;

+ Author Information


		Checking for direct PDF access through Ovid

Abstract

Transforming growth factor-beta (TGF-beta) is a potent inhibitor of epithelial cell growth. Human colon cancer cell lines with high rates of microsatellite instability were found to harbor mutations in the type II TGF-beta receptor (RII) gene. Eight such examples, due to three different mutations, were identified. The mutations were clustered within small repeated sequences in the RII gene, were accompanied by the absence of cell surface RII receptors, and were usually associated with small amounts of RII transcript. RII mutation, by inducing the escape of cells from TGF-beta-mediated growth control, links DNA repair defects with a specific pathway of tumor progression.


		Loading Related Articles

Inactivation of the Type II TGF-beta Receptor in Colon Cancer Cells with Microsatellite Instability

Abstract

Related Topics

Related Articles