A Human HP1 Pseudogene Maps to Chromosome 11p14

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Abstract

The chroma multigene superfamily encodes numerous proteins involved in chromatin structure or organization. The prototypical member of this superfamily is HP1 of Drosophila melanogaster We now present the sequence of a human HPlHsγ pseudogene and assign it to chromosome 11p14 by radiation hybrid mapping. The coding regions of at least three other human genes for HP1 orthologues and another pseudogene are very similar in sequence. These results demonstrate that HP1-type sequences have been duplicated multiple times in the mammalian genome.

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