Pharmacomechanical thrombolysis (PMT) has emerged as an alternate treatment used in most patients presenting with a thrombosed hemodialysis graft. Although the gold standard, surgical revision of thrombosed hemodialysis grafts is reserved for those cases of recurrent thrombosis despite the use of percutaneous techniques and for complicated cases after PMT. Nevertheless, as for every other procedure, PMT has its own set of limitations and cost issues. New mechanical devices have begun to emerge on the market to help accelerate clot dissolution with or without thrombolytic medications. These devices have decreased the time required to lyse clot and decrease the overall cost of percutaneous treatment. This article describes the use of the Microtherapeutics, Inc. (MTI) Castañeda over-the-wire brush and our experience with this device in the treatment of the clotted hemodialysis graft.