Neuroimaging is commonly utilized in the evaluation of post-cardiac arrest patients, providing a unique ability to visualize and quantify structural brain injury that can complement clinical and electrophysiologic data. Despite its lack of validation, we would advocate that neuroimaging is a valuable prognostication tool, worthy of further study, and an essential part of the armamentarium when used in combination with other modalities in the assessment of the post-cardiac arrest patient. Herein, we discuss the data and its limitations for neuroimaging to date and how it is being studied prospectively. We present current guidelines recommendations for prognostication after global hypoxic-ischemic injury, focusing primarily on computed tomography (CT) and magnetic resonance imaging (MRI), as they are the most widely used modalities. We present promising results from advanced neuroimaging techniques, and provide practical advice for the clinician caring for these patients in the real world.