Is there an interaction betweenBDKRB2−9/+9 andGNB3C825T polymorphisms and elite athletic performance?

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Abstract

The −9 deletion allele in theBDKRB2−9/+9 polymorphism was associated previously with improved endurance performance. We compared the frequency distribution of theBDKRB2−9/+9 (rs5810761) polymorphism between athletes (n=155) of sports with different demands (endurance runners;n=74 vs sprinters;n=81) as well as between athletes of different competitive levels (elite level;n=46 vs national level;n=109). These results were compared with those of 240 non-athletic healthy individuals. We also tested the influence of the interaction between theBDKRB2−9/+9 and theGNB3C825T (rs5443) genotypes in relation to endurance performance. Genotype distribution and allele frequencies were found to be similar in the endurance athlete, sprinter, and control groups (P=0.83 for genotype distribution andP=0.9 for allele frequencies). Similarly, no statistical differences were found between the subgroups of elite-level endurance athletes and national-level endurance athletes, or between elite-level and national-level sprinters (P>0.09 for all comparisons). There was no interaction betweenBDKRB2−9/+9 andGNB3C825T polymorphisms in relation to endurance performance (P=0.16 for interaction effect). In conclusion, theBDKRB2+9/−9 polymorphism is not associated with endurance performance, at least among Israeli athletes, and theGNB3TT+BDKRB2−9/−9 “optimal genotype” is not associated with endurance performance.

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