Kleine-Levin syndrome-like symptoms in a middle-aged female with cognitive dysfunction

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Abstract

Kleine-Levin syndrome is characterized by recurrent episodes of hypersomnia with cognitive and behavioral impairments. Two years ago, a 56-year-old female patient developed episodic memory loss and calculation difficulties. One year ago, she complained of recurrent hypersomnia with hyperphagia. Episodes developed 1–2 times per month and each episode lasted 3–4 days. Electroencephalography showed 6–7 Hz diffuse background slowing during an episode. Neuropsychological tests revealed cognitive impairment and brain imaging showed normal between episodes. Polysomnography showed increased periodic limb movement and respiratory disturbance index. This is the case of Kleine-Levin syndrome like symptoms in a patient with cognitive dysfunction.

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