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Clonidine might be beneficial to the patients undergoing laparoscopic cholecystectomy. This meta-analysis focused on the influence of clonidine on hemodynamic responses in patients undergoing laparoscopic cholecystectomy.We searched several databases including PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases. This meta-analysis included randomized controlled trials regarding the influence of clonidine versus placebo on laparoscopic cholecystectomy. The primary outcomes were mean arterial pressure (MAP) and heart rate (HR) at pneumoperitoneum. The random-effect model was applied for this study.Compared with control intervention, clonidine intervention was found to significantly reduce the MAP at pneumoperitoneum [standard mean difference=−2.58; 95% confidence interval (CI),−4.63 to −0.53; P=0.01), HR at pneumoperitoneum (standard mean difference=−3.67; 95% CI, −6.57 to −0.76; P=0.01), MAP at intubation (standard mean difference=−2.40; 95% CI, −4.75 to −0.06; P=0.04), HR at intubation (standard mean difference=−3.39; 95% CI, −5.75 to −1.02; P=0.005), propofol requirement (standard mean difference=−2.25; 95% CI, −4.01 to −0.48; P=0.01), as well as postoperative nausea and vomiting (risk ratio, 0.35; 95% CI, 0.19-0.63; P=0.0005).Compared with control intervention, clonidine intervention was found to significantly reduce MAP and HR at pneumoperitoneum and intubation, propofol requirement, as well as postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.